This phrase is a metaphor from baseball and it is typically used in the Dominican Republic. It means to go all the way with something, to fully commit or to push it to the limit.
Examples
- Spanish: Si vas a iniciar un negocio, tienes que meterlo hasta home. No puedes dudar ni un instante.
- English: If you're going to start a business, you have to go all the way. You can't doubt for a moment.